Acute tubulointerstitial nephritis (TIN) can cause acute kidney failure. It is characterized by presence of inflammatory cells in the renal interstitium, interstitial edema and renal tubules damage. Among many causes of TIN, the most important seems the drug-induced immune response, especially associated with antibiotics or non-steroidal anti-inflammatory drugs. Treatment of TIN is based on removal of causative agent and on anti-inflammatory treatment with steroids. The paper presents the case report of TIN. A kidney biopsy was performed for prolonged anuria. The patient required a transient 11-day renal replacement therapy and steroid course. Kidney function was restored.