Endophthalmitis is a rare, but potentially dangerous, condition that can lead to an irreversible vision loss. Inflammation develops in particular in immunocompromised patients who suffer from systemic diseases complicated by bacteriemia or candidiasis. In the case described, inflammation developed in a patient with long‑term, poorly controlled diabetes, diabetes‑related complications, right‑sided pneumonia, lower limb skin inflammation and urinary tract infected with Streptococcus agalactiae. Streptococcus B group is a common cause of intraocular inflammation, although Streptococcus agalactiae infection in adults is very rare. Treatment with systemic corticosteroids and broad‑spectrum antibiotics stopped the progression of intraocular inflammation and stabilized patient’s general condition.