Endometriosis is a chronic disease which mainly affects women in reproductive and deep infiltrating endometriosis (DIE) is a particular form of endometriosis that penetrates more than 5 mm under the peritoneal surface. Endometrial nodules may infiltrate different pelvic and abdominal organs and cause intense pain. Key symptoms are: cyclic pelvic pain related to menstruation and ovulation, deep dyspareunia, intestinal complaints associated with defecation, and infertility. Chronic pelvic pain, fatigue and urinary symptoms are also frequently observed. In the presence of this symptoms clinicians should particularly consider endometriosis, as such a diagnosis is still reported being made too late. Patients with suspected deep endometriosis should be referred to reference centers that offers treatment by a multidisciplinary specialist team.