A patient with coronavirus disease-2019 (COVID-19) treated in a temporary hospital presented symptoms of sudden respiratory failure, which in imaging studies indicated pneumothorax as the cause. The thoracic surgical intervention involving drainage of the pleural cavity initially brought the desired effect, but only for a short time. In the following days, new pneumothorax chambers requiring drainage were formed, due to pneumatocele as it turned out on CT scan. Drainage of life-threatening pneumatocelular pneumothorax is a minimally invasive and sufficient treatment procedure in COVID-19, and computed tomography should be a standard for symptoms of respiratory failure in already drained patients.