Basal cell carcinoma is the most common skin malignancy. Surgical excision is the basic treatment method. According to experts, the margin of macroscopically healthy tissue should be about 4 mm for primary lesions and about 10 mm for recurrence. The procedure is often associated with significant tissue defects. Facial lesions are often challenging because of the facial structure and the goal to maintain aesthetics. We describe a case of a patient with a third recurrence of basal cell carcinoma in the area of the left wing of the nose. Due to the expected significant loss of full-thickness tissues of the nasal wing, we planned reconstruction using two flaps: a lipocutaneous flap harvested from the nasolabial fold and a Mustarde rotation flap. The reconstruction was supplemented with split-thickness skin grafts. This approach allowed us to achieve full coverage of the tissue defect immediately after wide resection of the tumour. As a next step, we planned to reconstruct the nasal cartilage scaffold to improve nasal functionality and aesthetics. The described case is intended to present one of the reconstructive options for large post-resection tissue defects in the nasal wing area.