Chronic kidney disease refers to a group of disorders characterised by lasting abnormalities in kidney structure or function – persisting for over three months – and associated with conditions of various aetiologies. The classification of chronic kidney disease is based on two fundamental categories. The first one, marked as G, refers to the glomerular filtration rate, usually estimated using the CKD-EPI formula. The second, marked as A, relates to the amount of albumin excreted in the urine. Identifying the underlying causes of the disorders is essential, as targeted treatment can slow the natural progression of the disease and postpone the onset of the final, fifth stage – end-stage kidney disease – which necessitates the initiation of renal replacement therapy. The paper presents a case of a 50-year-old female patient with chronic kidney disease at stage G5 A3, with multiple comorbidities including suboptimally treated psoriasis, gout, recurrent urinary tract infections, and changes characteristic of xanthogranulomatous pyelonephritis of the right kidney, along with a history of chronic h ydronephrosis.