Systemic lupus erythematosus (SLE) is an autoimmune disease whose symptoms result from the deposition of immune complexes in various organs and lead to a chronic inflammatory process. The etiology of the disease is unknown. It also predisposes to other autoimmune diseases. One of them is antiphospholipid syndrome (APS) associated with the presence of antiphospholipid antibodies and the occurrence of venous thrombosis and obstetric failures. Another example is acquired hemophilia A (AHA), resulting from the presence of antibodies to coagulation factor VIII. Its main symptom is a hemorrhagic diathesis. Due to variety and multitude of diseases manifested as a consequence of SLE, the diagnosis and treatment that follows, are difficult to navigate. In this article we present a rare case of a patient with SLE, with predominantly renal manifestation and involvement of other organs, who developed both antiphospholipid syndrome and severe, acquired hemophilia A.