Left ventricular thrombus is one of the complications of ST-elevation myocardial infarction. Its presence is associated with the risk of serious embolic complications; therefore, diagnosis and effective treatment of formed thrombi are necessary. Suggested treatment methods include anticoagulation, thrombolysis and surgery, but there is no consensus on the choice of treatment method. We present a case report of a 52-year-old patient diagnosed with post-infarction left ventricular thrombus complicated by an embolic event. Due to the ineffective anticoagulant therapy, the patient underwent surgical removal of the thrombus, which resulted in its complete elimination from the left ventricle.