Management of post‑operative pain is a difficult task requiring multidisciplinary approach. The aim of the current study was to evaluate the characteristics and efficacy of treatment of post‑operative pain, and to assess the impact of selected factors on perceived pain by operated patients. The study was conducted in January and February 2014 on 100 patients subjected to different mode and extent of surgery. The patients’ data; data on pharmacotherapy and its efficacy, and data on impact of psychophysical factors on the patients status were analyzed. The VAS scale for pain was used. Remaining parameters were assessed based on the questionnaires created by the authors. The study showed that the level of pain decreased systematically after the operation. The mean level of pain on day 0, I, II, III and IV post‑surgery was 8.3  3.5, 7.4  2.9, 5.5  4.1 and 4.4  4.1, respectively. Lower level of pain was reported by patients with better emotional status, white‑collar workers, patients with planned and with smaller extent surgeries, slightly obese patients and those operated under spinal anesthesia. An increased level of pain was associated with increased arterial blood pressure, rate of breaths and pulse.