Traumatic brain injury (TBI) is one of the most common causes of hospitalization and interventions in emergency departments. Epidemiological studies show that their growth is the fastest in highly industrialized countries, ranging from 180 to 546 craniocerebral injuries per 100,000 people, of which approximately 10% are fatal. Head and neck injuries in the victim often coexist . Clinical post-traumatic syndrome is multi-symptomatic and it is often difficult to determine its severity in the first hours after the injury. New neuroimaging techniques have significantly improved the ability to detect early pathological changes following TBI. Nevertheless, the severity of the post TBI does not correlate with the results of neuroimaging tests and does not correlate with post-traumatic clinical sequelae.