Traumatic brain injury (TBI) poses a challenge to modern medicine because of its high incidence, varied clinical presentation, and the need for interdisciplinary treatment including often surgery, pharmacologic therapy, intensive care, nutritional therapy, and rehabilitation. Despite advances in the treatment of severe TBI, many patients require long-term care and do not gain self-reliance. For this reason, new therapies are still under evaluation, including neuroprotective treatment, which could improve prognosis after brain injury in both early and late stages. This paper presents a case of a patient with prolonged unconsciousness due to severe TBI, quadriparesis, and post-traumatic epilepsy despite intensive therapy and early rehabilitation, whose condition significantly improved after the use of a neurotrophic drug (cerebrolysin) and extensive rehabilitation with occupational therapy. Multidisciplinary management and multimodal therapy including neuroprotective treatment in TBI, is a promising management strategy that may contribute to therapeutic success.