Platelet parameters and metabolic disorders in patients with arterial hypertension
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Wydział Wojskowo‑Lekarski, Uniwersytet Medyczny w Łodzi; dziekan: prof. dr hab. med. Jurek Olszewski
Klinika Kardiologii i Chorób Wewnętrznych CSK MON WIM w Warszawie; kierownik: dr hab. n. med. Andrzej Skrobowski
Zakład Diagnostyki Laboratoryjnej CSK MON WIM w Warszawie; kierownik: dr hab. n. med. Agnieszka Woźniak‑Kosek
Submission date: 2017-02-28
Publication date: 2017-05-22
LW 2017;95(3):264-268
Introduction. Arterial hypertension (AH) frequently coexists with metabolic disorders, activated inflammatory and thrombogenic state, as well as increased secretion of adipokines. Mean platelet volume (MPV) and its ratio to platelet count (MPV/PLT) revealed to be related to cardiovascular risk. Aim. The evaluation of correlation between platelet parameters and laboratory indices of cardiometabolic disorders in hypertensives. Methods.In 137 subjects (94 males, mean age 44.9 years) with untreated AH the correlations of platelet parameters (MPV, PLT, MPV/PLT) with concentration of, among others, the following analytes: fasting glucose, LDL cholesterol, HDL cholesterol, triglycerides, creatinine and resistin were assessed, with special regard to gender. Results. There were no significant differences in mean values of platelet parameters between males and females. In females, MPV and MPV/PLT were significantly correlated with concentration of resisitin (R=0.43; p=0.005; R=0.39; p=0.011, respectively), creatinine (R=0.40; p=0.007; R=0.48. p=0.001) and HDL‑C (only for MPV/PLT: R=‑0.32; p=0.039). No such significant relations were observed in males. Conclusions. In hypertensive females the platelet parameters are associated with some cardiometabolic disorder indicators, that can be pathophysiologically relevant and should be further investigated.
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