Mechanical thrombectomy is a highly effective stroke therapy. Nonetheless, the routine methods (aspiration and/or stent retriever) sometimes fail to achieve satisfactory reperfusion. The treatment strategy in such cases is not yet strictly defined. This is a case of an unsuccessful mechanical thrombectomy for an intracranial atherosclerosis-related ischemic stroke with an occlusion in the M1 segment of the left middle cerebral artery. During the procedure, a full reperfusion was reached, but a persistent narrowing of the artery with a subsequent reoclusion was observed. The operator decided to perform rescue intracranial stenting combined with administration of glycoprotein IIb/IIIa inhibitor (GPI). The procedure resulted in a full and lasting reperfusion. On discharge the patient presented a significant neurological improvement. In 3-month follow-up he had only minor neurological symptoms that did not result in a disability of any kind (mRS 1) and in a 1-year follow-up he showed no neurological symptoms at all (mRS 0). This case indicates that rescue stenting combined with GPI administration might be safe and beneficial in patients treated for an intracranial atherosclerosis-related acute ischemic stroke with an unsuccessful mechanical thrombectomy.