The ongoing COVID-19 pandemic has hit the pediatric population in many ways. By disturbing or preventing in-person education in schools, students are often deprived of a supportive learning environment. In many cases, remote learning leads to decreased education quality. The reduction of peer contacts negatively impacts the psychological and emotional development of young people, which is confirmed by many researchers. In order to effectively limit the transmission of SARS-CoV-2 virus as well as other common viral infections in the school environment, appropriate preventive measures should be implemented. Maintaining the principles of physical distance, correct wearing of masks, adequate ventilation of closed spaces and hand hygiene are simple but effective tools in our fight against the COVID-19 pandemic. Moreover, thanks to the recent decision of the European Medicines Agency (EMA) , children over 6 months of age are given the opportunity to receive the most effective protection against COVID-19 in the form of vaccination using Comirnaty (Pfizer-BioNTech) or Spikevax (Moderna), both based on revolutionary mRNA technology. These recommendations are based on peer-reviewed scientific articles concerning COVID-19 in the pediatric population and the guidance from the Centers for Disease Control and Prevention (CDC). The presented guidelines should be widely implemented in schools so as to minimize the risk of COVID-19 outbreaks in the school environment and thus safely maintain in-person education, which is the most appropriate and beneficial for school-age children.