Acromegaly is a chronic disease, when significant functional and constitutional disorders of the body are caused by excessive secretion of growth hormone (GH) by a somatotroph pituitary adenoma. Long‑term prognosis and quality of life in acromegaly are particularly influenced by cardiovascular and respiratory system disorders. Early diagnosis of a somatotroph pituitary tumor and in‑depth morphological and function assessment of the cardiovascular and respiratory systems seem to be indispensable for stratifying the risk. Normalization of GH and/or IGF‑1 secretion by complex surgical and/or pharmacological treatment reduces mortality and risk of cardiovascular and respiratory complications. Therefore, the aim of this study was to present the complexity of clinical problems in acromegaly patients, who particularly require interdisciplinary treatment.