The main task of the holistic approach in medicine and health psychology is to seek and explore the backgrounds and attitudes which are helpful in coping with a disease and its effects and, in consequence, deriving satisfaction from one’s life. The quality of life evaluation shows statistically significant differences between healthy subjects and the group of chronically ill; at the same time, no significant differences were observed between singled groups of chronically ill, i.e. asthmatics and patients with hypertension. Life satisfaction assessment results of healthy and chronically ill people vary significantly in five key life areas. Not unexpectedly, the greatest discrepancies arose in the assessment of their own health. Second came the area of satisfaction from sexual activity, then the financial situation, which, again, seems obvious as it is a direct effect of work opportunities and expenses associated with treatment. Subsequent noticeable differences arose between the control group and the chronically ill in relation to the sense of satisfaction with themselves and with their marriage. The lowest quality of life rates relate to asthmatics and patients with cancer.