52‑year‑old man, without any history of chronic diseases, admitted to the Gastroenterology Department due to recurrent abdominal pain, numerous dyspeptic symptoms, weight loss and edema around the ankles. Laboratory blood tests showed exponents of chronic kidney disease and gastrointestinal inflammation (suggesting Crohn disease) was found in the endoscopic examination of the gastrointestinal tract. Due to ECG abnormalities and increased cardiac troponin concentration, the patient was referred for cardiology consultation. Based on the echo result, considering the overall clinical presentation, heart amyloidosis was suspected. No amyloid deposits have been identified in further diagnostic tests but the kappa light chains have been identified by immunofixation of serum proteins. Patient was transferred to the Hematooncology Department where the diagnosis of myeloma (IgG kappa) was made based on the bone marrow biopsy. Multiple myeloma and amyloidosis are diseases belonging to the group of plasma cell dyscrasias, which may coexist, and therefore should be taken into account during the differential diagnosis.