Introduction: Contemporary oral surgery focuses on minimally invasive techniques and methods that support tissue healing and regeneration. One of the modern approaches involves the use of platelet-rich plasma (PRP), a concentrated plasma fraction containing platelets and growth factors such as PDGF, TGF-β, and VEGF, which play key roles in regenerative processes and angiogenesis. PRP has wide applications in oral surgery, including procedures such as tooth extractions, implant placements, bone augmentations, and soft tissue regeneration. Due to its pro-regenerative and anti-inflammatory properties, PRP contributes to shorter recovery times, reduced pain, and improved quality of newly formed tissue. Material and methods: A systematic review of the literature from the PubMed database was conducted to analyse publications on the use of PRP in dental surgery. Conclusions: PRP is a promising tool supporting tissue regeneration in dental surgery due to the presence of multiple growth factors that play an essential role in angiogenesis, cellular proliferation, and extracellular matrix remodeling. In the context of tooth extraction, PRP helps reduce pain, swelling, and the risk of complications, while also accelerating soft tissue regeneration. For bone augmentation procedures, it supports osteogenesis, particularly when combined with bone substitute materials, although its effectiveness depends on several factors, such as the quality of the biomaterial and surgical technique. PRP used in sinus lift and implantology has shown moderate outcomes, and its efficacy in promoting peri-implant tissue regeneration remains a subject of debate. In periodontology, PRP supports soft tissue and periodontal regeneration, accelerating wound healing and the restoration of connective tissue attachment. PRP represents a valuable adjunct in oral surgery; however, given the lack of clear evidence on its efficacy in bone regeneration, further clinical studies and standardization of PRP preparation and application methods are needed.