Toxic epidermal necrolysis (TEN) and Stevens‑Johnson Syndrome (SJS) are severe adverse drug reactions that involve the skin and mucous membranes. They are expressed by hemorrhagic erosions, erythema and more or less severe epidermal detachment presenting as blisters and areas of denuded skin. Drugs are assumed or identified as the main cause of SJS/TEN in most cases. Diagnosis relies mainly on clinical signs together with the histological analysis of a skin biopsy showing typical full‑thickness epidermal necrolysis due to extensive keratinocyte apoptosis. To reduce the high risk of mortality, management requires prompt diagnosis, determination and removal of the cause, assessment of prognosis (e.g. using the SCORTEN scale), rapid implementation of appropriate care and treatment (using immunomodulatory drugs, such as intravenous immunoglobulin) and sometimes treatment in the intensive care unit.